Research from Russian Academy of Sciences (RAS) Has Provided New Data on Pharmaceutics (Derivatives of Pyrimidine Nucleosides Affect Artificial Membranes Enriched with Mycobacterial Lipids).

A recent report from the Russian Academy of Sciences (RAS) discusses research on the effects of pyrimidine nucleoside derivatives on model lipid membranes. The study found that the ability of these derivatives to disrupt membrane lipids depended on the types of nucleoside bases and membrane-forming lipids. Additionally, the research discovered that certain compounds were able to form ion-permeable pores in membranes enriched with mycobacterial lipids. These findings have potential implications for the development of selective anti-tuberculosis agents that directly target the pathogen's membranes. [Extracted from the article]