Study Results from First Hospital of Jilin University Broaden Understanding of Klebsiella pneumoniae (Ginkgolic Acid as a carbapenem synergist against KPC-2 positive Klebsiella pneumoniae).

A study conducted at the First Hospital of Jilin University in China has found that Ginkgolic Acid (GA) can effectively inhibit the KPC-2 enzyme in Klebsiella pneumoniae, a type of bacteria that has developed resistance to carbapenem antibiotics. The researchers discovered that GA can enhance the killing effect of carbapenems on KPC-2-positive Klebsiella pneumoniae by binding to the active pocket of the enzyme. Additionally, GA was found to disrupt the integrity of the bacterial membrane, further increasing the bactericidal ability of carbapenems. This study suggests that GA could be a promising inhibitor of KPC-2 and improve the prognosis of patients with carbapenem-resistant infections. [Extracted from the article]