Investigators from University of Washington Zero in on Biosensors (Single-cell Sensor Analyses Reveal Signaling Programs Enabling Ras-g12c Drug Resistance).

A report from the University of Washington discusses research on biosensors and their role in understanding drug resistance in cancer cells. The study focused on the adaptive effects of Ras-G12C inhibitors on Ras signaling at the single-cell level. The researchers used Ras biosensors to analyze the activity and signaling environment of Ras in cancer cells and found that certain cells underwent adaptive signaling and metabolic changes in response to the drugs. The study identified major vault protein as a mediator of Ras activation and highlighted the importance of single-cell analysis in understanding drug resistance. [Extracted from the article]