Multi-Omics Unveils Strain-Specific Neuroactive Metabolite Production Linked to Inflammation Modulation by Bacteroides and Their Extracellular Vesicles.

A recent study investigated the production of neuroactive metabolites by different strains of Bacteroides, a type of bacteria found in the human gut. The study found that these bacteria have the potential to produce various compounds linked to neurotransmitter metabolism, including GABA, tryptophan, tyrosine, and histidine. The researchers also discovered that Bacteroides produce extracellular vesicles (EVs) that contain neuroactive metabolites, with GABA being the most abundant. The study suggests that these metabolites, particularly GABA, play a role in modulating inflammation and immune responses. However, it is important to note that this study has not yet undergone peer review. [Extracted from the article]