New Data from Peking University Illuminate Findings in Xenografts (Dehydroepiandrosterone Attenuated the Immune Escape of Oral Squamous Cell Carcinoma Through Nf-kb P65/mir-15b-5p/b7-h4 Axis).

A recent study conducted at Peking University in Beijing, China, explored the effects of dehydroepiandrosterone (DHEA) on immune evasion in oral squamous cell carcinoma (OSCC). The researchers used a xenograft mouse model and immunohistochemistry to examine tumor-infiltrating lymphocytes (TILs). The study found that DHEA inhibited tumor growth, increased CD8+ cells, and decreased FOXP3+ cells in TILs. It also reduced the expression of B7-H4, a protein associated with immune escape in OSCC. The findings suggest that DHEA could be used to enhance the effectiveness of immunotherapy for OSCC. [Extracted from the article]