Indications for Reduced-Dose Direct Oral Anticoagulants.

The article examines the safety of reduced-dose edoxaban in elderly patients with atrial fibrillation, highlighting that the lower dose significantly reduces major bleeding without increasing stroke risk compared to both the higher dose and warfarin. Topics include the effectiveness of reduced-dose edoxaban for patients aged 80 and older, its impact on bleeding and stroke rates, and the implications for patients undergoing transcutaneous aortic valve replacement.