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RNA in cardiovascular disease: A new frontier of personalized medicine.

Authors :
Abdul-Rahman, Toufik
Lizano-Jubert, Ileana
Bliss, Zarah Sophia Blake
Garg, Neil
Meale, Emily
Roy, Poulami
Crino, Salvatore Antonio
Deepak, Bethineedi Lakshmi
Miteu, Goshen David
Wireko, Andrew Awuah
Qadeer, Abdul
Condurat, Alexandra
Tanasa, Andra Diana
Pyrpyris, Nikolaos
Sikora, Kateryna
Horbas, Viktoriia
Sood, Aayushi
Gupta, Rahul
Lavie, Carl J.
Source :
Progress in Cardiovascular Diseases; Jul2024, Vol. 85, p93-102, 10p
Publication Year :
2024

Abstract

Personalized medicine has witnessed remarkable progress with the emergence of RNA therapy, offering new possibilities for the treatment of various diseases, and in particular in the context of cardiovascular disease (CVD). The ability to target the human genome through RNA manipulation offers great potential not only in the treatment of cardiac pathologies but also in their diagnosis and prevention, notably in cases of hyperlipidemia and myocardial infarctions. While only a few RNA-based treatments have entered clinical trials or obtained approval from the US Food and Drug Administration, the growing body of research on this subject is promising. However, the development of RNA therapies faces several challenges that must be overcome. These include the efficient delivery of drugs into cells, the potential for immunogenic responses, and safety. Resolving these obstacles is crucial to advance the development of RNA therapies. This review explores the newest developments in medical studies, treatment plans, and results related to RNA therapies for heart disease. Furthermore, it discusses the exciting possibilities and difficulties in this innovative area of research. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00330620
Volume :
85
Database :
Supplemental Index
Journal :
Progress in Cardiovascular Diseases
Publication Type :
Academic Journal
Accession number :
179088103
Full Text :
https://doi.org/10.1016/j.pcad.2024.01.016