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Short-term effects of Roux-en-Y gastric bypass or gastric sleeve on bone mineral density and calciotropic hormones: a systematic review and meta-analysis.
- Source :
- Surgery for Obesity & Related Diseases; Aug2024, Vol. 20 Issue 8, p774-783, 10p
- Publication Year :
- 2024
-
Abstract
- Roux-en-Y gastric bypass (RYGB) and gastric sleeve (GS) have been associated with significant reductions in bone mineral density (BMD) and fluctuations in serum levels of calciotropic hormones. These changes pose a risk to bone health. The study assessed the short-term (12 and 24 months) effects of RYGB and GS on BMD and calciotropic hormones. PubMed, Embase, and Cochrane Library databases were searched. Analyses considered follow-up (12 and 24 months) with BMD as main outcome at three sites (femoral neck, total hip, and lumbar spine) and one for each calciotropic hormone (25 OH vitamin D and parathyroid hormone [PTH]). Estimated effect sizes were calculated as standardized mean differences (SMD), confidence interval of 95%, and P value. Nine studies totaling 473 participants (RYGB = 261 and GS = 212) were included. RYGB resulted in lower BMD than GS at 12 months for femoral neck (SMD = −0.485, 95% CI [−0.768, −0.202], P =.001), lumbar spine (SMD = −0.471, 95% CI [−0.851, −0.092], P =.015), and total hip (SMD = −0.616, 95% CI [−0.972, −0.259], P =.001), and at 24 months for total hip (SMD = −0.572, 95% CI [−0.907, −0.238], P =.001). At 24 months, 25 OH vitamin D was lower in RYGB than GS (SMD = −0.958 [−1.670, −0.245], P =.008) and PTH levels were higher in RYGB than in GS (SMD = 0.968 [0.132, 1.804, P =.023]). RYGB demonstrated significant reduction in regional BMD. It also induces lower serum 25 OH vitamin D and higher PTH levels than GS. The results support the need for preventive bone health measures in the short-term postoperative period, especially in the case of RYGB. • At 12 and 24 months, RYGB reduced regional DMO more than GS. • Parathyroid hormone (PTH) was higher in the RYGB compared to the GS. • Serum 25-OH vitamin D was higher in the RYGB compared to the GS. • In the short-term, RYGB compared to GS was more detrimental to bone health. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15507289
- Volume :
- 20
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- Surgery for Obesity & Related Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 179062360
- Full Text :
- https://doi.org/10.1016/j.soard.2024.03.007