Study Results from Karolinska Institute Broaden Understanding of Puumala Virus (Innate Lymphoid Cells Are Activated In Hfrs, and Their Function Can Be Modulated By Hantavirus-induced Type I Interferons).

A recent study conducted by researchers at the Karolinska Institute in Stockholm, Sweden, has shed light on the activation and function of innate lymphoid cells (ILCs) in patients with hemorrhagic fever with renal syndrome (HFRS) caused by the Puumala virus. The study found that HFRS patients had an increased frequency of ILC2s in their blood and that these cells displayed an activated profile with altered expression of certain markers. The researchers also discovered that the activation of ILCs during viral infection is dependent on type I interferons, which suggests a role for these antiviral molecules in shaping ILC functions. These findings contribute to a better understanding of the immune response to hantavirus infections and may have implications for the development of therapeutic interventions. [Extracted from the article]