Lack of pathogenic involvement of CCL4 and its receptor CCR5 in arthritogenic alphavirus disease.

A recent preprint study investigated the role of chemokine C ligand 4 (CCL4) and its receptor C-C chemokine receptor type 5 (CCR5) in arthritogenic alphavirus disease. The study focused on alphaviruses such as chikungunya virus (CHIKV), Mayaro virus (MAYV), Ross River virus (RRV), and O nyong nyong virus (ONNV), which cause fever, rash, and joint swelling. The researchers found that CCL4 and CCR5 did not have a significant impact on disease progression or virus replication in mice infected with MAYV. These findings suggest that CCL4 and CCR5 may not play a major role in the development of arthritogenic alphavirus disease. However, it is important to note that this study has not yet undergone peer review. [Extracted from the article]