Propranolol reduces Parkinson's tremor and inhibits tremor-related activity in the motor cortex: a placebo-controlled crossover trial.

A recent study investigated the effects of propranolol, a non-selective beta-adrenergic receptor antagonist, on Parkinson's disease (PD) tremor. The study found that propranolol reduced tremor severity and tremor-related brain activity in PD patients. The researchers also discovered that stress worsened tremor and that the noradrenergic system may play a role in amplifying tremor. These findings suggest that the noradrenergic system has a general, context-independent role in amplifying PD tremor at the level of the primary motor cortex. However, it is important to note that this study has not yet undergone peer review. [Extracted from the article]