Researchers from University of Jinan Describe Findings in Staphylococcus aureus (Neutrophil-mimicking Nanozyme With Cascade Catalytic Releasing Nitric Oxide and Signet Oxygen Property for Synergistic Bimodal Therapy of Methicillin-resistant...).

Researchers from the University of Jinan in Guangzhou, China, have developed a neutrophil-mimicking nanozyme for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. The nanozyme, called MGBC, has high delivery efficiency and self-supplies hydrogen peroxide (H2O2) to generate highly active signet oxygen (O-1(2)). It also releases nitric oxide (NO) for gas therapy, resulting in a synergistic bimodal therapy that effectively kills MRSA and eradicates MRSA biofilms. The research found that the nanozyme downregulates genes related to drug resistance, toxicity, and biofilm formation in MRSA. This study provides insights into the development of new treatments for MRSA infections. [Extracted from the article]