Researchers at Washington University Release New Data on Central Nervous System Agents (Potentiation of the Gaba a R Reveals Variable Energetic Contributions By Etiocholanolone and Propofol).

Researchers at Washington University have released new data on central nervous system agents, specifically the potentiation of the GABA A receptor by etiocholanolone and propofol. The study examined the relationship between receptor potentiation and background activity, finding that the free energy change contributed by the modulators is reduced at higher levels of control activity, which contradicts the coagonist model. The researchers discuss possible mechanisms underlying this discrepancy. This research has been peer-reviewed and published in the Biophysical Journal. [Extracted from the article]