Circulating mucosal-like IgA responses associate with severity of Puumala orthohantavirus-caused hemorrhagic fever with renal syndrome.

A recent preprint study examined the immune response in patients with acute Puumala orthohantavirus infection, which causes hemorrhagic fever with renal syndrome (HFRS). The study found that patients with more severe kidney injury had higher levels of circulating virus-specific and secretory IgA, a type of antibody. Additionally, the study found that excessive activation of the mucosal immune system may contribute to the progression of HFRS. This research provides insights into the immune response during HFRS and suggests that a balance in mucosal immune activation is important for infection clearance. However, it is important to note that this study has not yet undergone peer review. [Extracted from the article]