Researchers from Jamia Hamdard University Detail New Studies and Findings in the Area of Chandipura Virus (Chandipura Virus Forms Cytoplasmic Inclusion Bodies through Phase Separation and Proviral Association of Cellular Protein Kinase R and...).

A recent report discusses research on the Chandipura virus, an emerging human pathogen that causes influenza-like illness and encephalitis with a high mortality rate. The study aimed to understand how the virus forms cytoplasmic inclusion bodies (IBs) and evades antiviral stress granules (SGs). The researchers found that Chandipura virus infection does not induce the formation of distinct SGs but instead forms heterogeneous IBs that co-localize with SG proteins. Depletion of certain cellular proteins decreased viral transcription and virion production, suggesting a proviral role for these proteins. Understanding the mechanisms of Chandipura virus replication could aid in the development of effective therapeutics against the virus. [Extracted from the article]