PRC1.6 localizes on chromatin with the human silencing hub (HUSH) complex for promoter-specific silencing (Updated July 13, 2024).

A recent preprint abstract discusses the mechanisms underlying the regulation of proviruses, which are retroviruses that establish themselves in target cell chromosomes. The study focuses on the Human Silencing Hub (HUSH) complex, which represses provirus expression. The researchers developed a technique called Provirus Proximal Proteomics to identify proteins associated with HUSH complex-repressed proviruses in human cells. They found that the non-canonical polycomb repressive complex 1.6 (PRC1.6) is involved in silencing proviruses in a promoter-specific manner, and there is crosstalk between the HUSH complex and PRC1.6. This research provides new tools for studying the transcriptional regulation of proviruses. [Extracted from the article]