Targeting ABC transporters in PDAC - past, present, or future?

A new editorial paper published in Oncotarget discusses the targeting of ABC transporters in pancreatic ductal carcinoma (PDAC). PDAC is the third leading cause of cancer mortality in the US and the sixth worldwide, with low survival rates. ABC transporters are a family of proteins that can contribute to resistance against chemotherapy drugs. The paper suggests that developing a stratification protocol to identify PDAC patients who are most likely to benefit from inhibitors of ABC transporters could be crucial for future treatment. [Extracted from the article]