Weill Cornell Medicine Researchers Have Published New Data on Proviruses (HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy).

Researchers from Weill Cornell Medicine have published new data on proviruses, which are a primary obstacle to curing HIV-1. Previous studies have mainly focused on males in the United States and Europe with HIV-1 subtype B, but less is known about proviral landscapes in females with non-B subtypes, who represent the largest group of individuals living with HIV-1. The researchers analyzed genomic DNA from Ugandan individuals receiving suppressive antiretroviral therapy and found that intact proviral genomes were relatively rare, and clonal expansion occurred in both intact and defective genomes. This research will contribute to understanding HIV-1 persistence and cure strategies in Africa, where the burden of HIV-1 is highest. [Extracted from the article]