Integrated Approach for the Management of Osteonecrosis: Photodynamic Therapy and Hyperbaric Chamber Synergy.

This study explores an innovative therapeutic strategy by integrating photodynamic therapy (PDT) and hyperbaric chamber treatment for effective osteonecrosis management. A 65-year-old male with metastatic prostate cancer, receiving Zometa® treatment, presented bilateral mandibular exposed bone, causing pain. A multidisciplinary approach was employed, using topical antiseptics, PDT sessions, and hyperbaric therapy to address the complex condition. During follow-up, the patient underwent sequestrectomy due to bone sequestration. Subsequent tissue repair occurred smoothly, and the patient remained asymptomatic for three years post-treatment. This integrated approach shows promise in managing osteonecrosis, addressing microbial burden, and enhancing tissue repair. PDT and hyperbaric therapy offer a comprehensive solution for osteonecrosis. Further investigations are essential to validate and refine this approach, potentially establishing it as a standard protocol in oral medicine. [ABSTRACT FROM AUTHOR]