Research from Capital Medical University Has Provided New Data on Androgen Insensitivity Syndrome (Analysis of genetic and clinical characteristics of androgen insensitivity syndrome: a cohort study including 12 families).

A recent study conducted by researchers at Capital Medical University in Beijing, China, examined the genetic and clinical characteristics of individuals with androgen insensitivity syndrome (AIS). AIS is a condition that affects individuals with 46, XY disorders and is caused by variants in the androgen receptor (AR) gene. The study found that most patients with complete AIS (CAIS) maintained their female gender, while those with partial AIS (PAIS) were raised as males. The researchers also identified various AR gene variants, with some being inherited from mothers and even maternal grandfathers. The study suggests that fertility preservation should be considered when evaluating gonadectomy in AIS patients. [Extracted from the article]