Researcher's Work from University of Groningen Focuses on Lactic Acidosis (Comprehensive GC-MS Measurement of Amino Acids, Metabolites, and Malondialdehyde in Metformin-Associated Lactic Acidosis at Admission and during Renal Replacement...).

A recent study conducted at the University of Groningen in the Netherlands focused on lactic acidosis, a condition associated with the use of the drug metformin in type 2 diabetes. The study used stable-isotope labeled GC-MS methods to measure amino acids and metabolites in plasma, urine, and dialysate samples from a patient with metformin-associated lactic acidosis. The results showed lower concentrations of amino acids in plasma, normal concentrations of nitric oxide metabolites, and normal concentrations of malondialdehyde, an oxidative stress biomarker. The study suggests that GC-MS is a versatile analytical tool for measuring different substances in complex biological samples in clinical settings. [Extracted from the article]