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Serum metabolic profiling in pregnant Holstein cows 3 weeks prior to parturition using two-dimensional gas chromatography time-of-flight mass spectrometry.
- Source :
- Journal of Veterinary Medical Science; 2024, Vol. 86 Issue 6, p606-611, 6p
- Publication Year :
- 2024
-
Abstract
- This preliminary study explored potential serum biomarkers for predicting the onset of milk fever (MF), a bovine parturient disease with hypocalcemia. We conducted two-dimensional gas chromatography mass spectrometry-based metabolomics in 8 and 17 pregnant Holstein cows that did and did not develop MF 3 weeks later, respectively. In principal component analysis (PCA) applied to a dataset containing 1,498 metabolites, serum metabolites exhibited highly similar chemical profiles between cows with and without MF. PCA with a limited dataset of metabolites containing fatty acids, which had significantly different values between the groups and/or correlation coefficients of >0.5 for the serum calcium concentration, distinguished the two groups. These suggest the possibility of developing serum biomarkers for predicting bovine MF. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09167250
- Volume :
- 86
- Issue :
- 6
- Database :
- Supplemental Index
- Journal :
- Journal of Veterinary Medical Science
- Publication Type :
- Academic Journal
- Accession number :
- 178376352
- Full Text :
- https://doi.org/10.1292/jvms.24-0091