Adjunctive hyperbaric oxygen treatment for challenging pyoderma gangrenosum cases.

Pyoderma gangrenosum (PG) is a rare, difficult-to-treat neutrophilic ulcerative cutaneous condition that severely impacts those affected. Treatment options for PG are limited, and disease remission is not guaranteed. Hyperbaric oxygen treatment is a potential therapeutic option for treating various ulcerative conditions not frequently utilized for PG. We present a case of a patient with treatment-resistant PG who achieved remission with adjunctive HBOT, and then later had difficulty achieving remission without HBOT during a future flare. HBOT should be more readily considered as a treatment option for those with PG. • Pyoderma gangrenosum (PG) is a rare, often debilitating ulcerative cutaneous condition that can be very difficult to treat. • Hyperbaric oxygen treatment (HBOT) can promote wound healing and is utilized for several conditions involving tissue injury. • We present a case of a patient with refractory PG who had successful wound healing by adding HBOT as an adjunctive measure. • HBOT should be considered as a potential treatment option for PG. [ABSTRACT FROM AUTHOR]