Findings from University of Arizona Has Provided New Data on Postpartum Hemorrhage (A Common oxtr Risk Variant Alters Regulation of Gene Expression By Dna Hydroxymethylation In Pregnant Human Myometrium).

A recent study conducted by the University of Arizona has provided new data on postpartum hemorrhage, a common complication after childbirth. The research found that a genetic variant in the oxytocin receptor gene (OXTR) interacts with epigenetic factors, specifically DNA hydroxymethylation, to affect gene expression in the myometrium, the muscle layer of the uterus. This interaction also has implications for clinical outcomes such as the quantity of oxytocin administration and the odds of experiencing postpartum hemorrhage. The findings offer potential avenues for predicting how women will respond to pharmacological agents in the prevention and treatment of postpartum hemorrhage. [Extracted from the article]