Overcoming Challenges in Preregistration to Improve Statistical Inferences in Clinical Science (Updated June 20, 2024).

This article discusses the benefits of preregistration in clinical science research. Preregistration involves registering hypotheses and analysis plans on a public registry before conducting the research, which promotes transparency and guards against selective reporting. It also improves the validity of planned analyses and allows for calibration of confidence in unplanned analyses. The article addresses the challenges of preregistration in clinical science and provides strategies for overcoming these challenges. It is important for researchers to consider preregistration to improve the rigor and validity of their studies. [Extracted from the article]