Abdullah Gul University Researchers Have Published New Data on Factor V (Membrane binding and lipid-protein interaction of the C2 domain from coagulation factor V).

Researchers from Abdullah Gul University in Kayseri, Turkey have conducted a study on factor V, a blood coagulation factor. The study focused on the C2 domain of factor V and its role in anchoring coagulation factors to the membrane. Through molecular dynamics simulations, the researchers observed the spontaneous binding of the C2 domain to a specific lipid-containing membrane. They also identified a putative binding site for phosphatidylserine, suggesting a different orientation compared to previous proposals. The study provides insights into the conformational dynamics and lipid-protein interactions of factor V. [Extracted from the article]