Unravelling biological processess and EGFR pathway regulation by the receptor-like protein tyrosine phosphatase PTPRH in non-small cell lung cancer.

A preprint abstract from biorxiv.org discusses the role of the receptor-like protein tyrosine phosphatase PTPRH in non-small cell lung cancer (NSCLC). The study found that PTPRH is deregulated or mutated in NSCLC and is involved in the regulation of the EGFR pathway. Knockout of PTPRH in NSCLC cells increased phosphorylation levels of EGFR, while overexpression of PTPRH decreased phosphorylation. The study also revealed that PTPRH interacts with NF-{kappa}B, a transcription factor downstream of the EGFR pathway, and is primarily involved in translation and RNA-associated pathways. These findings provide insight into the importance of PTPRH in regulating biological and cellular processes and its potential role in cancer progression. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]