Study Findings on Human Papillomavirus 16 Reported by Researchers at Central South University [PAX1 methylation as a robust predictor: developing and validating a nomogram for assessing endocervical curettage (ECC) necessity in human...].

Researchers at Central South University have developed a nomogram that can predict the necessity of endocervical curettage (ECC) in women with human papillomavirus (HPV) 16/18 infection. The nomogram combines clinical characteristics with the assessment of paired boxed gene 1 methylation levels (PAX1m) to improve the accuracy of detecting high-grade squamous intraepithelial lesions or worse (HSIL +) through ECC. The study found that age, cytology, and PAX1 methylation levels were independent predictive factors for additional detection of HSIL + by ECC. The nomogram demonstrated high sensitivity and specificity, making it a valuable tool for guiding clinical decisions regarding ECC in HPV 16/18-positive women. [Extracted from the article]