Mater Misericordiae University Hospital Researchers Add New Data to Research in Genetics (Management of pregnancy in women with monogenic diabetes due to mutations in GCK, HNF1A and HNF4A genes).

Researchers at Mater Misericordiae University Hospital in Dublin, Ireland have conducted a study on the management of pregnancy in women with monogenic diabetes caused by mutations in GCK, HNF1A, and HNF4A genes. The study found that women with maturity-onset diabetes of the young (MODY) require tailored antenatal care and monitoring of their offspring. Different MODY subtypes have different implications for treatment and neonatal management. The researchers recommend genetic diagnosis and precision treatment during pregnancy. The study also discusses the implications for pregnancies affected by a positive paternal genotype and the use of cell-free fetal DNA in maternal blood for distinguishing fetal genotype. [Extracted from the article]