An expanded metabolic pathway for androgen production by host-associated bacteria.

A recent preprint abstract suggests that host-associated bacteria may play a role in the production of androgens, which could have implications for androgen-related diseases. The researchers identified a microbial gene in the gut bacterium Clostridium scindens that encodes an enzyme involved in the conversion of androstenedione to epitestosterone. Contrary to current beliefs, the researchers found that epitestosterone is a potent androgen that promotes prostate cancer cell growth. They also discovered that bacterial isolates from urine and prostatectomy tissue are capable of androgen production. These findings highlight the importance of studying microbial biotransformations in relation to androgen-mediated processes and diseases. However, it is important to note that this research has not yet undergone peer review. [Extracted from the article]