Researchers at University of Wurzburg Report Research in Immunology (Acid ceramidase expression reduces IFNg secretion by mouse CD4+ T cells and is crucial for maintaining B-cell numbers in mice).

A recent report from researchers at the University of Wurzburg in Germany explores the role of acid ceramidase (Ac) in immune responses, specifically anti-viral immunity. The study utilized a tamoxifen-inducible global knockout mouse model to investigate the impact of Ac expression on various leukocyte populations. The findings suggest that Ac plays a crucial role in maintaining B-cell numbers and reducing IFNg secretion by CD4+ T cells. This research provides valuable insights into the potential therapeutic applications of Ac inhibitors in cancer treatment. [Extracted from the article]