Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel.

Sortilin, a lipoprotein receptor, has been found to play a role in brain lipid metabolism and health. It mediates the uptake of polyunsaturated fatty acids carried by apoE, which are then converted into ligands for PPARalpha. This enables neurons to use long-chain fatty acids as an alternative metabolic fuel, particularly when glucose supply is limited in the aging brain. However, this pathway is disrupted by the AD risk factor apoE4. This information is based on a preprint abstract and has not been peer-reviewed. [Extracted from the article]