GATA3 and TGF-β in normal placenta and pre-eclampsia.

GATA3 plays critical roles in the development and function of various tissues and organs throughout the body. Likewise, TGF-β signaling is critical for placental development and can interact with GATA3. We aimed to investigate the involvement of the multifunctional cytokine and transcription factor in trophoblast development. By using immunohistochemistry, we evaluated the localization and expression level of GATA3 and TGF-β in placentas at term of normal pregnancy and with pre-eclampsia. Up-regulation of both GATA3 and TGF-β was observed in pathological placentas, with localization in the villus epithelium (syncytiotrophoblast) stroma and decidua. Our data show altered expression of TGF-β and GATA3, which downstream could lead to a cascade of events that negatively influence trophoblast development and contribute to the pathogenesis of pre-eclampsia. • GATA3 is involved in placental development, regulating expression of genes crucial for trophoblast invasion/differentiation. • Dysregulation of GATA3 expression/function can lead to placental defects and pregnancy complications such as pre-eclampsia. • The interplay between GATA3 and TGF-β is crucial in understanding placental development and disorders like pre-eclampsia. • Both GATA3 and TGF-β show increased expression in pre-eclampsia placentas compared to normal ones. • Their interaction may modulate processes like trophoblast EMT cells, impacting trophoblast invasion and placental function. [ABSTRACT FROM AUTHOR]