Investigators at Icahn School of Medicine at Mount Sinai Describe Findings in Life Science (Structural Pharmacology and Therapeutic Potential of 5-methoxytryptamines).

A recent study conducted at the Icahn School of Medicine at Mount Sinai explores the structural pharmacology and therapeutic potential of 5-methoxytryptamines, a class of psychedelic substances. The research focuses on the serotonin receptor 5-HT1A and its role in the behavioral effects of tryptamine hallucinogens, particularly 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT). Through cryogenic electron microscopy and other techniques, the study identifies the molecular determinants of 5-HT1A signaling potency, efficacy, and selectivity. The findings may contribute to the development of new medications for neuropsychiatric disorders. [Extracted from the article]