Development of Thin-Film Light-Emitting Devices for Hyper Localized Photodynamic Therapy.

In this study, we fabricated a thin-film light-emitting device to apply metronomic photodynamic therapy (PDT) in a weak light emitted by LED chips that showed the PDT effect at the cellular level. Thin-film light-emitting devices can operate an LED chip by the wireless power supply. This device has been developed by exploiting a flexible antenna coil made from Au nanoparticle ink printed on a 5-μm-thick poly(D, L-lactic acid) thin film. The weak light intensity of LED (10∼400 µW/cm²) can direct the cell death regions. Further quantification of mPDT at the cellular level as well as in vivo evaluation, will be carried out. [ABSTRACT FROM AUTHOR]