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Micronized dry emulsion with solid nanocore: A novel strategy to incorporate a large amount of ceramides.
- Source :
- Journal of Industrial & Engineering Chemistry; Jul2024, Vol. 135, p596-602, 7p
- Publication Year :
- 2024
-
Abstract
- [Display omitted] Conventional oil-in-water or water-in-oil emulsions that serve as carriers for drugs and other hydrophobic substances eventually break down and undergo phase separation, coalescence, creaming, and/or flocculation. To overcome this issue, we fabricated dry emulsions with solid cores that can encapsulate high amount of ceramides with high hydrophobicity (logP>9) via spray drying. Based on pseudo-ternary diagrams of 50 formulations, 5 nanoemulsions with an optimum particle size (∼200 nm) and good storage stability (4 weeks) were selected and used to fabricate core-shell-type dry emulsions with ceramides (cDEs). These cDEs were microsized spheres and incorporated 15-23 % (w/w) of ceramides in emulsions. The solid-core cDEs 5 and 6 well-reconstituted in water, presented good colloidal stability with low polydispersity (PDI<0.15), and were smaller than those of DEs with liquid cores. Moreover, the selected DEs exhibited particle sizes of 4–7 μm and reconstituted to a submicron size. We believe that our cDEs could be a tool to encapsulate poorly soluble ceramides and other insoluble bioactive compounds in commercial products. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1226086X
- Volume :
- 135
- Database :
- Supplemental Index
- Journal :
- Journal of Industrial & Engineering Chemistry
- Publication Type :
- Periodical
- Accession number :
- 177373239
- Full Text :
- https://doi.org/10.1016/j.jiec.2024.03.035