Kinase Suppressor of Ras 2 promotes self-renewal and clonogenicity of small-cell lung carcinoma (Updated May 8, 2024).

A recent preprint abstract from biorxiv.org discusses the role of Kinase Suppressor of Ras 2 (KSR2) in small-cell lung carcinoma (SCLC). The study found that KSR2 promotes the self-renewal and clonogenicity of SCLC cells, particularly in the ASCL1 subtype of SCLC tumors. KSR2 is expressed in pulmonary neuroendocrine cells, which are one of the identified cells of origin for SCLC-A tumors. Disruption of KSR2 inhibits the colony forming ability of tumor propagating cells in vitro and their tumor initiating capacity in vivo. These findings suggest that KSR2 may be a potential therapeutic target for ASCL1-subtype SCLC tumors. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]