Investigators at College of Basic and Applied Sciences Detail Findings in Antineoplastics [Evaluation of the Anti-pcos Potential of Ethanolic Extract of ocimum Gratissimum (Linn.) Leaf In Letrozole-induced Polycystic Ovarian Syndrome In...].

A recent study conducted in Ogun State, Nigeria, explored the potential of the ethanolic extract of Ocimum gratissimum leaves (EEOGL) in treating letrozole-induced polycystic ovarian syndrome (PCOS). The study involved administering EEOGL to rats with PCOS and evaluating its effects on various hormones and lipids. The results showed that EEOGL at a dose of 50 mg/kg significantly decreased insulin, testosterone, luteinizing hormone, low-density lipoprotein, total cholesterol, and triglyceride levels, while increasing follicle-stimulating hormone, estradiol, and high-density lipoprotein levels. However, the higher dose of 100 mg/kg did not reverse elevated insulin and luteinizing hormone levels. Molecular docking analysis also identified four compounds with high binding affinity for the proteins studied. The study suggests that O. gratissimum extracts have the potential to regulate reproductive-induced alterations in PCOS rats. [Extracted from the article]