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Lipoprotein(a) levels and carotid intima-media thickness in children: A 20-year follow-up study.
- Source :
- Journal of Clinical Lipidology; Mar2024, Vol. 18 Issue 2, pe290-e294, 5p
- Publication Year :
- 2024
-
Abstract
- • 88 children without FH were followed-up for 20 years. • Lp(a) and cIMT were measured at baseline and after 10- and 20 years. • At baseline, Lp(a) was elevated in 11.1% of the children. • Lp(a) did not contribute significantly to arterial wall thickening (measured by cIMT). Elevated lipoprotein(a) [Lp(a)] is independently associated with cardiovascular disease (CVD). In a recent long-term follow-up study involving children with familial hypercholesterolemia (FH), Lp(a) levels contributed significantly to early atherosclerosis, as measured by carotid intima-media thickness (cIMT). To determine if this holds true for children without FH, we conducted a 20-year follow-up study, examining 88 unaffected siblings (mean age: 12.9 years) of children with FH. No significant association was found between Lp(a) and cIMT during follow-up (ß-adjusted [95% confidence interval] = 0.0001 [-0.008 to 0.008] mm per 50 nmol/L increase Lp(a), p = 0.97). In conclusion, our findings suggest that elevated levels of Lp(a) do not play a significant role in arterial wall thickening among children without FH during the 20-year follow-up period. This leads us to consider the possibility that cIMT may not be a suitable marker for detecting potential subtle changes in the arterial wall mediated by Lp(a) in the young, general population. However, it could also be that elevated Lp(a) is only a significant risk factor for atherosclerosis in the presence of other risk factors such as FH. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19332874
- Volume :
- 18
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Journal of Clinical Lipidology
- Publication Type :
- Academic Journal
- Accession number :
- 176925172
- Full Text :
- https://doi.org/10.1016/j.jacl.2023.11.014