MicroRNA-27a-5p downregulates the expression of proinflammatory cytokines in lipopolysaccharide-stimulated human dental pulp cells via NF-kB signaling pathway.

A preprint abstract from biorxiv.org discusses the effect of microRNA-27a-5p (miR-27a-5p) on the expression of proinflammatory cytokines in human dental pulp cells (hDPCs) stimulated by lipopolysaccharide (LPS). The study found that LPS-stimulated hDPCs showed increased expression of miR-27a-5p and proinflammatory cytokines, which was suppressed by an NF-kB inhibitor. Transfection of the miR-27a-5p mimic downregulated the expression of proinflammatory cytokines and NF-kB activity in hDPCs. The study suggests that miR-27a-5p negatively regulates the synthesis of proinflammatory cytokines by targeting the NF-kB signaling pathway. [Extracted from the article]