Study Results from Princess Royal University Hospital Provide New Insights into Eosinophilic Esophagitis (Circulating immunome fingerprint in eosinophilic esophagitis is associated with clinical response to proton pump inhibitor treatment).

A recent study conducted at Princess Royal University Hospital in Madrid, Spain, aimed to identify potential non-invasive biomarkers of treatment response for eosinophilic esophagitis (EoE) patients undergoing proton pump inhibitor (PPI) treatment. The study found that EoE patients at baseline had lower levels of circulating plasmacytoid dendritic cells (pDC) compared to healthy controls. However, patients who responded to PPI therapy had higher levels of circulating pDC and classical monocytes before treatment. Following PPI therapy, pDC levels increased in all EoE patients, but normal levels were only restored in responders. The study suggests that circulating pDC may serve as a novel non-invasive biomarker to predict response to PPI treatment in EoE patients. [Extracted from the article]