"Instrument For Performing A Diagnostic Test On A Fluidic Cartridge" in Patent Application Approval Process (USPTO 20240109069).

The patent application by Ben Arlett and Tom Edwards describes an instrument called a cartridge reader that is designed to perform diagnostic tests on fluidic cartridges. The invention aims to address logistical challenges in sample preparation and analysis by allowing tests to be conducted on-site in local GP surgeries. The reader includes a mechanical valve and an actuation system controlled by an electromagnet, which helps prevent sample contamination. The invention also improves upon conventional potentiostats by generating better signals for electrochemical assays. The method involves moving the lower clamp, activating the electromagnet, inserting the cartridge, moving the lower clamp again, and deactivating the electromagnet to actuate the isolation valve. The fluidic cartridge itself includes a front end for sample preparation and a back end for nucleic acid analysis, with an isolation valve controlled by a flexible membrane and an actuator. [Extracted from the article]