Study Data from Kyushu University Provide New Insights into Artificial Nucleic Acids (Development of an Artificial Nucleic Acid Skeleton Allowing for Unnatural-type Triplex Dna Formation With Duplex Dna Having a Ta Inversion Site).

A study conducted at Kyushu University in Fukuoka, Japan, has explored the development of artificial nucleic acids that can recognize TA base pairs. Triplex DNA formation, which directly targets duplex DNA, has been limited by the base pairs of target duplex DNA sequences. The researchers focused on a benzimidazole skeleton and introduced a hydroxyl group to enable one-point hydrogen bonding. The study found that the artificial nucleoside analogues with a hydroxyl group successfully recognized TA base pairs for all four different sequences. This research provides new insights into the development of artificial nucleic acids for TA base pair recognition. [Extracted from the article]