Reports on Recombinant Proteins Findings from National Autonomous University of Mexico (UNAM) Provide New Insights (Expression In Cho Cells of a Bacterial Biosynthetic Pathway Producing a Small Non-ribosomal Peptide Aldehyde Prevents...).

A study conducted at the National Autonomous University of Mexico (UNAM) has found that proteolysis, a common problem during recombinant protein production, can be prevented by expressing a bacterial biosynthetic pathway in CHO cells. The researchers discovered that the expression of the livipeptin biosynthetic pathway in CHO cells resulted in the production of a protease inhibitor without adverse effects on cell growth or viability. This finding expands the field of metabolic engineering of mammalian cells and offers a new option for proteolysis inhibition in bioprocess engineering. The research has been peer-reviewed and published in the journal Metabolic Engineering. [Extracted from the article]