National Institute for Viral Disease Control and Prevention Researcher Reports on Findings in Mastadenovirus (The Biodistribution of Replication-Defective Simian Adenovirus 1 Vector in a Mouse Model).

A study conducted by researchers at the National Institute for Viral Disease Control and Prevention in Beijing, China, investigated the biodistribution of a gene transfer vector called SAdV1-GFluc in a mouse model. The researchers found that the administration route affected the biodistribution and expression of the transgene. Intravenous administration resulted in luciferase activity and virus DNA mainly found in the liver and spleen, while intragastric administration led to transient, low-level expression. Intranasal administration resulted in moderate, constant expression in the respiratory tract, and intramuscular administration showed high luciferase activity restricted to the injection site. The study suggests that intranasal or intramuscular administration may be preferred routes for the SAdV-1 vector in vaccine development. [Extracted from the article]