Studies in the Area of Pyroptosis Reported from Chinese Academy of Sciences (Programmed Targeting Pyruvate Metabolism Therapy Amplified Single-atom Nanozyme-activated Pyroptosis for Immunotherapy).

A research report from the Chinese Academy of Sciences discusses the use of a novel single-atom nanozyme pyroptosis initiator called Cu-NS@UK@POx for immunotherapy. This nanozyme triggers pyroptosis, a form of cell death, to enhance the immunogenicity of tumor cells and remodel the immunosuppressive tumor microenvironment. By targeting pyruvate metabolism, this treatment strategy activates antitumor immunotherapy effects and shows promise for expanding immunotherapy options. The research was supported by various funding sources and has been peer-reviewed. [Extracted from the article]