Reports Outline Osteoarthritis Study Results from University of Calgary (Tryptase ss Regulation of Joint Lubrication and Inflammation Via Proteoglycan-4 In Osteoarthritis).

A report from the University of Calgary discusses the role of a protein called PRG4 in osteoarthritis, a joint inflammatory disease. The research found that an enzyme called mast cell tryptase ss can cleave PRG4, leading to a reduction in joint lubrication and activation of NF-.B expression, which is associated with inflammation. The study also observed the colocalization of tryptase ss and PRG4 at the site of injury in knee cartilage in a rat model of osteoarthritis. The findings suggest that tryptase ss may play a role in modulating joint lubrication in osteoarthritis. [Extracted from the article]