Data on Nanopharmaceuticals Discussed by Researchers at Liaocheng University (Construction of l-carnitine-modified Tpgs Micelles To Achieve Oral Delivery of Camptothecin and Targeted Anticancer Effects).

Researchers at Liaocheng University in the People's Republic of China have developed an oral nanodrug delivery carrier for anticancer drugs. The carrier, called l-carnitine-modified alpha-tocopherol acid poly(ethylene glycol) succinate (Lc-TPGS), enhances the absorption of the drug camptothecin (CPT) in the intestine and allows for targeted delivery to tumors. In vitro and in vivo experiments showed that the Lc-TPGS-based nanosystems had efficient cellular uptake and selective accumulation at the tumor site, resulting in effective anticancer activity with minimal side effects. This research provides promising advancements in the field of nanopharmaceuticals for cancer treatment. [Extracted from the article]