Researchers at Shandong University Target Nanocoatings (A Multifunctional Metal-phenolic Nanocoating On Bone Implants for Enhanced Osseointegration Via Early Immunomodulation).

Researchers at Shandong University in Jinan, China have developed a metal-phenolic nanocoating for bone implants that enhances osseointegration through early immunomodulation. The nanocoating, made of tannic acid and Sr2+, provides a bioactive interface that promotes the adhesion and recruitment of bone marrow mesenchymal stem cells and polarizes macrophages towards an M2 phenotype. The nanocoating also accelerates osteogenic differentiation and enhances osseointegration around the implant. This research suggests that the metal-phenolic nanocoating is a promising strategy for achieving better and faster osseointegration of bone implants, with potential for future clinical applications. [Extracted from the article]