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Hepatic arterial hemodynamics and model for end-stage liver disease (MELD) scores in chronic liver disease: insights from Doppler ultrasonography.
- Source :
- Egyptian Journal of Radiology & Nuclear Medicine; 3/26/2024, Vol. 55 Issue 1, p1-8, 8p
- Publication Year :
- 2024
-
Abstract
- Background: Doppler ultrasonography is essential to provide insights into hemodynamic alterations and liver function changes in pre-cirrhotic and cirrhotic patients. Utilizing Doppler examinations, this study aims to explore the correlation between hepatic arterial hemodynamics and Model for end-stage liver disease (MELD) scores in chronic liver disease patients. Methods: A study of 50 chronic liver disease patients included sonographic assessments, measuring liver, portal vein size, and flow. Hepatic artery velocity, resistive index (RI), pulsatility index (PI), and acceleration time (AT) were evaluated. Biochemical parameters (serum bilirubin, creatinine, INR) were used to calculate MELD scores, compared with different Doppler sonographic parameters. Results: The study found a mean peak systolic velocity (PSV) of 107.42 ± 48.10, with end-diastolic velocity (EDV) of 26.40 ± 14.68, RI of 0.74 ± 0.06, and PI of 1.47 ± 0.24. The mean MELD score was 19.28 ± 6.09. Correlations between MELD scores and PSV, EDV, RI, PI, and AT did not yield statistically significant correlations. 80% of subjects displayed high RI (> 0.7) values in the hepatic artery, and a significant correlation was found between portal vein thrombosis and hepatic artery PSV and RI (p < 0.05). Conclusions: Hepatic artery RI and PSV show a significant correlation with portal vein thrombosis. Doppler ultrasonography, while not directly tied to MELD scores, is valuable for non-invasive liver disease monitoring when invasive methods are impractical. Further research is needed to unravel the relationships between hemodynamic changes, MELD scores, and clinical outcomes in a broader patient population. [ABSTRACT FROM AUTHOR]
- Subjects :
- LIVER physiology
PREDICTIVE tests
PEARSON correlation (Statistics)
PORTAL vein
HEPATIC artery
DOPPLER ultrasonography
STATISTICAL hypothesis testing
T-test (Statistics)
PHENOMENOLOGICAL biology
SCIENTIFIC observation
VENOUS thrombosis
HEMODYNAMICS
DESCRIPTIVE statistics
SEVERITY of illness index
BIOCHEMISTRY
LIVER diseases
LONGITUDINAL method
BLOOD flow measurement
STATISTICS
DATA analysis software
LIVER transplantation
REGRESSION analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0378603X
- Volume :
- 55
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Egyptian Journal of Radiology & Nuclear Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 176265328
- Full Text :
- https://doi.org/10.1186/s43055-024-01220-3